Reduced TORC1 signaling abolishes mitochondrial dysfunctions and shortened chronological lifespan of Isc1p-deficient cells

@inproceedings{Teixeira2014ReducedTS,
  title={Reduced TORC1 signaling abolishes mitochondrial dysfunctions and
shortened chronological lifespan of Isc1p-deficient cells},
  author={Vitor Teixeira and T{\^a}nia Catarina Medeiros and Rita Vilaça and Pedro Moradas-Ferreira and V{\'i}tor Costa},
  booktitle={Microbial cell},
  year={2014}
}
The target of rapamycin (TOR) is an important signaling pathway on a hierarchical network of interacting pathways regulating central biological processes, such as cell growth, stress response and aging. Several lines of evidence suggest a functional link between TOR signaling and sphingolipid metabolism. Here, we report that the TORC1-Sch9p pathway is activated in cells lacking Isc1p, the yeast orthologue of mammalian neutral sphingomyelinase 2. The deletion of TOR1 or SCH9 abolishes the… CONTINUE READING

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