Reduced Skeletal Muscle Inhibitor of κBβ Content Is Associated With Insulin Resistance in Subjects With Type 2 Diabetes: Reversal by Exercise Training

@article{Sriwijitkamol2006ReducedSM,
  title={Reduced Skeletal Muscle Inhibitor of $\kappa$B$\beta$ Content Is Associated With Insulin Resistance in Subjects With Type 2 Diabetes: Reversal by Exercise Training},
  author={A. Sriwijitkamol and C. Christ-Roberts and R. Berria and P. Eagan and T. Pratipanawatr and R. DeFronzo and L. Mandarino and N. Musi},
  journal={Diabetes},
  year={2006},
  volume={55},
  pages={760-767}
}
Skeletal muscle insulin resistance plays a key role in the pathogenesis of type 2 diabetes. It recently has been hypothesized that excessive activity of the inhibitor of κB (IκB)/nuclear factor κB (NFκB) inflammatory pathway is a mechanism underlying skeletal muscle insulin resistance. However, it is not known whether IκB/NFκB signaling in muscle from subjects with type 2 diabetes is abnormal. We studied IκB/NFκB signaling in vastus lateralis muscle from six subjects with type 2 diabetes and… Expand
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