Reduced Serotonin-1A Receptor Binding in Social Anxiety Disorder

  title={Reduced Serotonin-1A Receptor Binding in Social Anxiety Disorder},
  author={R. Lanzenberger and M. Mitterhauser and C. Spindelegger and W. Wadsak and J. Tauscher},
  journal={Biological Psychiatry},
  • R. Lanzenberger, M. Mitterhauser, +2 authors J. Tauscher
  • Published 2007
  • Psychology, Medicine
  • Biological Psychiatry
  • BACKGROUND Results from studies in serotonin-1A (5-HT1A) knockout mice and previous positron emission tomography (PET) studies in humans imply a role for 5-HT1A receptors in normal state anxiety as well as in certain anxiety disorders. The objective of this study was to investigate 5-HT1A receptor binding potential (BP) in social anxiety disorder (SAD). METHODS Using PET and [carbonyl-11C]WAY-100635, we compared a homogeneous group of 12 unmedicated, male SAD patients with 18 healthy control… CONTINUE READING
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