Reduced Serotonin-1A Receptor Binding in Social Anxiety Disorder
@article{Lanzenberger2007ReducedSR, title={Reduced Serotonin-1A Receptor Binding in Social Anxiety Disorder}, author={R. Lanzenberger and M. Mitterhauser and C. Spindelegger and W. Wadsak and J. Tauscher}, journal={Biological Psychiatry}, year={2007}, volume={61}, pages={1081-1089} }
BACKGROUND
Results from studies in serotonin-1A (5-HT1A) knockout mice and previous positron emission tomography (PET) studies in humans imply a role for 5-HT1A receptors in normal state anxiety as well as in certain anxiety disorders. The objective of this study was to investigate 5-HT1A receptor binding potential (BP) in social anxiety disorder (SAD).
METHODS
Using PET and [carbonyl-11C]WAY-100635, we compared a homogeneous group of 12 unmedicated, male SAD patients with 18 healthy control… Expand
Topics from this paper
254 Citations
Serotonin 5-HT1A receptor binding in people with panic disorder: positron emission tomography study.
- Psychology, Medicine
- The British journal of psychiatry : the journal of mental science
- 2008
- 156
- PDF
Progesterone Level Predicts Serotonin-1A Receptor Binding in the Male Human Brain
- Psychology, Medicine
- Neuroendocrinology
- 2011
- 18
Serotonin Synthesis and Reuptake in Social Anxiety Disorder: A Positron Emission Tomography Study.
- Psychology, Medicine
- JAMA psychiatry
- 2015
- 71
- PDF
Extrastriatal dopamine D2-receptor availability in social anxiety disorder
- Psychology, Medicine
- European Neuropsychopharmacology
- 2017
- 22
Central serotonin 1A receptor binding in temporal lobe epilepsy: A [carbonyl-11C]WAY-100635 PET study
- Psychology, Medicine
- Epilepsy & Behavior
- 2010
- 30
5-HT1A receptor function in major depressive disorder
- Psychology, Medicine
- Progress in Neurobiology
- 2009
- 450
Influence of escitalopram treatment on 5-HT1A receptor binding in limbic regions in patients with anxiety disorders
- Psychology, Medicine
- Molecular Psychiatry
- 2009
- 92
- PDF
References
SHOWING 1-10 OF 78 REFERENCES
Brain Serotonin1A Receptor Binding in Major Depression Is Related to Psychic and Somatic Anxiety
- Psychology, Medicine
- Biological Psychiatry
- 2005
- 69
Reduced Serotonin Type 1A Receptor Binding in Panic Disorder
- Psychology, Medicine
- The Journal of Neuroscience
- 2004
- 330
- PDF
Pet imaging of serotonin 1A receptor binding in depression
- Psychology, Medicine
- Biological Psychiatry
- 1999
- 642
- PDF
Inverse relationship between serotonin 5-HT(1A) receptor binding and anxiety: a [(11)C]WAY-100635 PET investigation in healthy volunteers.
- Psychology, Medicine
- The American journal of psychiatry
- 2001
- 126
Altered Serotonin 1A Binding in Major Depression: A [carbonyl-C-11]WAY100635 Positron Emission Tomography Study
- Psychology, Medicine
- Biological Psychiatry
- 2006
- 345
Serotonin receptor 1A knockout: an animal model of anxiety-related disorder.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1998
- 799
- PDF
Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635.
- Medicine, Psychology
- Archives of general psychiatry
- 2005
- 157
- PDF
Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635
- Psychology, Medicine
- Brain Research
- 2002
- 284
Serotonin 5-HT1A Receptor Binding Potential Declines with Age as Measured by [11C]WAY-100635 and PET
- Psychology, Medicine
- Neuropsychopharmacology
- 2001
- 116
- PDF
Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635
- Psychology, Medicine
- Molecular Psychiatry
- 2004
- 235
- PDF