Reduced Secretion of YopJ by Yersinia Limits In Vivo Cell Death but Enhances Bacterial Virulence

Abstract

Numerous microbial pathogens modulate or interfere with cell death pathways in cultured cells. However, the precise role of host cell death during in vivo infection remains poorly understood. Macrophages infected by pathogenic species of Yersinia typically undergo an apoptotic cell death. This is due to the activity of a Type III secreted effector protein… (More)
DOI: 10.1371/journal.ppat.1000067

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@article{Brodsky2008ReducedSO, title={Reduced Secretion of YopJ by Yersinia Limits In Vivo Cell Death but Enhances Bacterial Virulence}, author={Igor E Brodsky and Ruslan Medzhitov}, journal={PLoS Pathogens}, year={2008}, volume={4}, pages={7 - 13} }