Reduced SOD activity and increased neural tube defects in embryos of the sensitive but not of the resistant Cohen diabetic rats cultured under diabetic conditions.

@article{WekslerZangen2003ReducedSA,
  title={Reduced SOD activity and increased neural tube defects in embryos of the sensitive but not of the resistant Cohen diabetic rats cultured under diabetic conditions.},
  author={Sarah Weksler-Zangen and Pirhiya Yaffe and Asher Ornoy},
  journal={Birth defects research. Part A, Clinical and molecular teratology},
  year={2003},
  volume={67 6},
  pages={429-37}
}
BACKGROUND The role of reactive oxygen species in the etiology of diabetes-induced anomalies was studied in a genetic model of nutritionally induced Type 2 diabetes mellitus: the Cohen diabetic sensitive (CDs) and resistant (CDr) rats. We have previously shown in this model that embryopathy may be induced by a combination of genetic and environmental factors. In our study we investigated the role of the antioxidant defense mechanism, genetic predisposition or environmental factors in embryos… CONTINUE READING