Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis

  title={Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis},
  author={G. Fossati and Raffaella Morini and Irene Corradini and Francesca Antonucci and Philipp Trepte and Efrat Edry and Vikram Sharma and Alessandro Papale and Davide Pozzi and Paola Defilippi and Jochen C Meier and Riccardo Brambilla and E. Turco and Kobi Rosenblum and Erich E. Wanker and Noam E. Ziv and Elisabetta Menna and Michela Matteoli},
  journal={Cell Death and Differentiation},
Impairment of synaptic function can lead to neuropsychiatric disorders collectively referred to as synaptopathies. The SNARE protein SNAP-25 is implicated in several brain pathologies and, indeed, brain areas of psychiatric patients often display reduced SNAP-25 expression. It has been recently found that acute downregulation of SNAP-25 in brain slices impairs long-term potentiation; however, the processes through which this occurs are still poorly defined. We show that in vivo acute… CONTINUE READING
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