Reduced Risk of Plasmodium vivax Malaria in Papua New Guinean Children with Southeast Asian Ovalocytosis in Two Cohorts and a Case-Control Study

@inproceedings{RosanasUrgell2012ReducedRO,
  title={Reduced Risk of Plasmodium vivax Malaria in Papua New Guinean Children with Southeast Asian Ovalocytosis in Two Cohorts and a Case-Control Study},
  author={Anna Rosanas-Urgell and Enmoore Lin and Laurens Manning and Patricia Rarau and Moses Laman and Nicolas Senn and Brian T Grimberg and Livingstone Tavul and Danielle I. Stanisic and Leanne J Robinson and J Javier Aponte and Elijah Dabod and John C Reeder and Peter Siba and Peter A Zimmerman and Timothy M. E. Davis and Christopher L King and Pascal Michon and Ivo Mueller},
  booktitle={PLoS medicine},
  year={2012}
}
BACKGROUND The erythrocyte polymorphism, Southeast Asian ovalocytosis (SAO) (which results from a 27-base pair deletion in the erythrocyte band 3 gene, SLC4A1Δ27) protects against cerebral malaria caused by Plasmodium falciparum; however, it is unknown whether this polymorphism also protects against P. vivax infection and disease. METHODS AND FINDINGS The association between SAO and P. vivax infection was examined through genotyping of 1,975 children enrolled in three independent… CONTINUE READING
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Efficacy of intermittent preventive treatment for malaria in Papua New Guinean infants exposed to Plasmodium falciparum and P. vivax

  • N Senn, P Rarau, D Stanisic, L Robinson, C Barnadas
  • PLoS Medicine 9:
  • 2012
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