Reduced Rif2 and no Mec1 targets short telomeres for elongation rather than double-strand break repair

@inproceedings{McGee2010ReducedRA,
  title={Reduced Rif2 and no Mec1 targets short telomeres for elongation rather than double-strand break repair},
  author={Jean Suh McGee and Jane Anna Phillips and Angela P. S. Chan and Michelle Sabourin and Katrin Paeschke and Virginia A. Zakian},
  booktitle={Nature Structural &Molecular Biology},
  year={2010}
}
Telomerase in Saccharomyces cerevisiae binds and preferentially elongates short telomeres, and this process requires the checkpoint kinase Tel1. Here we show that the Mre11 complex bound preferentially to short telomeres, which could explain the preferential binding of Tel1 to these ends. Compared to wild-type length telomeres, short telomeres generated by incomplete replication had low levels of the telomerase inhibitory protein Rif2. Moreover, in the absence of Rif2, Tel1 bound equally well… CONTINUE READING
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