Reduced Reperfusion – Induced Ins ( 1 , 4 , 5 ) P 3 Generation and Arrhythmias in Hearts Expressing Constitutively Active a 1 B-Adrenergic Receptors

Abstract

Reperfusion of globally ischemic rat hearts causes the generation of inositol(1,4,5)trisphosphate [Ins(1,4,5)P3] and the initiation of arrhythmias. These responses are mediated by a1-adrenergic receptors (ARs), but the subtype of receptor involved has not been identified. Under normoxic conditions, hearts from transgenic animals expressing constitutively… (More)

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