Reduced RanBPM Expression Is Associated with Distant Metastasis in Gastric Cancer and Chemoresistance.

@article{Shao2016ReducedRE,
  title={Reduced RanBPM Expression Is Associated with Distant Metastasis in Gastric Cancer and Chemoresistance.},
  author={Shuai Shao and Ping-Hui Sun and Lucy K. Satherley and Xiangyu Gao and K E Ji and Y I Feng and Yongning Jia and Jiafu Ji and Wen Jiang and Lin Ye},
  journal={Anticancer research},
  year={2016},
  volume={36 3},
  pages={1295-303}
}
AIM Ran binding protein M (RanBPM) is a ubiquitous, nucleocytoplasmic protein that serves as a scaffolding molecule. This study aimed to investigate the role of RanBPM in gastric cancer. MATERIALS AND METHODS RanBPM expression in human gastric cancer tissue samples was analyzed using real-time polymerase chain reaction. The effect of RanBPM on cellular functions was examined in RanBPM-knockdown gastric cells and with in vitro cell functional assays. RESULTS Gastric tumors with distant… CONTINUE READING