Reduced R2' in multiple sclerosis normal appearing white matter and lesions may reflect decreased myelin and iron content.

@article{Paling2012ReducedRI,
  title={Reduced R2' in multiple sclerosis normal appearing white matter and lesions may reflect decreased myelin and iron content.},
  author={David Paling and Daniel J. Tozer and Claudia A. M. Wheeler-Kingshott and Raju Kapoor and David H. Miller and Xavier Golay},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2012},
  volume={83 8},
  pages={785-92}
}
BACKGROUND R(2)' is an MRI measure of microscopic magnetic field inhomogeneity, and is increased by the paramagnetic effect of iron and the diamagnetic effect of myelin. R(2)' may detect features of multiple sclerosis (MS) not evident with conventional MRI. METHODS Multiecho T(2) and T(2)* weighted sequences were obtained from 21 healthy controls (nine… CONTINUE READING

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