Reduced Purkinje cell number in essential tremor: a postmortem study.

@article{Axelrad2008ReducedPC,
  title={Reduced Purkinje cell number in essential tremor: a postmortem study.},
  author={Jordan E. Axelrad and Elan Daniel Louis and Lawrence S. Honig and Ingrid M. Flores and G. Webster Ross and Rajesh Pahwa and Kelly E. Lyons and Phyllis L. Faust and Jean Paul G. Vonsattel},
  journal={Archives of neurology},
  year={2008},
  volume={65 1},
  pages={
          101-7
        }
}
BACKGROUND Clinical and functional imaging evidence suggests that cerebellar dysfunction occurs in essential tremor (ET). In recent postmortem studies, we documented increased numbers of torpedoes (Purkinje cell axonal swellings) in ET patients without Lewy bodies. Purkinje cell loss, however, has never been rigorously assessed. OBJECTIVE To quantitatively assess the number of Purkinje cells in brains of ET patients and similarly aged controls. METHODS Postmortem cerebellar tissue was… CONTINUE READING
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Essential tremor

  • ED Louis
  • Lancet Neurol ;4(2):100–110
  • 2005

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