Reduced Pax2 gene dosage increases apoptosis and slows the progression of renal cystic disease.

@article{Ostrom2000ReducedPG,
  title={Reduced Pax2 gene dosage increases apoptosis and slows the progression of renal cystic disease.},
  author={L Ostrom and Michelle J. Tang and P. Gruss and Gregory R Dressler},
  journal={Developmental biology},
  year={2000},
  volume={219 2},
  pages={250-8}
}
The murine cpk mouse develops a rapid-onset polycystic kidney disease (PKD) with many similarities to human PKD. During kidney development, the transcription factor Pax2 is required for the specification and differentiation of the renal epithelium. In humans, Pax2 is also expressed in juvenile cystic kidneys where it correlates with cell proliferation. In this report, Pax2 expression is demonstrated in the cystic epithelium of the mouse cpk kidneys. To assess the role of Pax2 during the… CONTINUE READING