Reduced PTEN Protein in Human Bladder Cancer Patients Hyperplasia and Carcinomas in Pten-Deficient Mice and Updated Version

Abstract

PTEN is a tumor suppressor gene mutated in many human cancers. We used the Cre-loxP system to generate an urothelium-specific null mutation of Pten in mice [FabpCrePten (FPten) mice]. Histologic examination revealed that all FPten mice exhibited urothelial hyperplasia in which component cells showed enlarged nuclei and increased cell size. With time, 10% of… (More)

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@inproceedings{Tsuruta2006ReducedPP, title={Reduced PTEN Protein in Human Bladder Cancer Patients Hyperplasia and Carcinomas in Pten-Deficient Mice and Updated Version}, author={Hiroshi Tsuruta and Hiroyuki Kishimoto and Takehiko Sasaki and Yasuo Horie and Miyuki Natsui and Yoshiko Shibata and Koichi Hamada and Nobuyuki Yajima and Koichi Kawahara and Masato Sasaki and Norihiko Tsuchiya and Katsuhiko Enomoto and Tak W Mak and Toru Nakano and Tomonori Habuchi and Akira K Suzuki}, year={2006} }