Reduced NO signaling during pregnancy attenuates outward uterine artery remodeling by altering MMP expression and collagen and elastin deposition.

@article{Hale2011ReducedNS,
  title={Reduced NO signaling during pregnancy attenuates outward uterine artery remodeling by altering MMP expression and collagen and elastin deposition.},
  author={Sarah A Hale and Lindsey Weger and Maurizio Mandal{\'a} and George J Osol},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2011},
  volume={301 4},
  pages={H1266-75}
}
Recent findings indicate that endothelial nitric oxide (NO) plays a key role in uterine artery outward circumferential remodeling during pregnancy. Although the underlying mechanisms are not known, they likely involve matrix metalloproteinases (MMPs). The goal of this study was to examine the linkage among NO inhibition, expansive remodeling, and MMP expression within the uterine vascular wall. Adult female rats were treated with N(G)-nitro-L-arginine methyl ester [L-NAME (LPLN)] beginning on… CONTINUE READING
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Comparative assessment of matrix metalloproteinase (MMP)-2 and MMP-9, and their inhibitors, tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 in H1274 NO DECREASES MMP EXPRESSION AJP-Heart

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Matrix metalloproteinase-2, -9, and tissue inhibitor of metal H1273 NO DECREASES MMP EXPRESSION AJP-Heart

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