Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding.

@article{Rizzo2010ReducedNS,
  title={Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding.},
  author={Norma O. Rizzo and Ezekiel Maloney and Matilda Pham and Ian P. Luttrell and Hunter Wessells and Sanshiro Tateya and Guenter Daum and Priya Handa and Michael J. Schwartz and Francis Y. Kim},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2010},
  volume={30 4},
  pages={758-65}
}
OBJECTIVE Diet-induced obesity (DIO) in mice causes vascular inflammation and insulin resistance that are accompanied by decreased endothelial-derived NO production. We sought to determine whether reduced NO-cGMP signaling contributes to the deleterious effects of DIO on the vasculature and, if so, whether these effects can be blocked by increased vascular NO-cGMP signaling. METHODS AND RESULTS By using an established endothelial cell culture model of insulin resistance, exposure to palmitate… CONTINUE READING

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C57BL6 mice were either fed a high - fat diet or remained on a low - fat diet for 8 weeks .
In high - fat diet - fed mice , vascular inflammation and insulin resistance were completely prevented by sildenafil administration at a dose that had no effect in mice fed the low - fat diet .
In high - fat diet - fed mice , vascular inflammation and insulin resistance were completely prevented by sildenafil administration at a dose that had no effect in mice fed the low - fat diet .
C57BL6 mice were either fed a high - fat diet or remained on a low - fat diet for 8 weeks .
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