Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier.

@article{Jalil2005ReducedNL,
  title={Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier.},
  author={Md Abdul Jalil and Laila Begum and Laura Contreras and Beatriz Pardo and Mikio Iijima and Meng Xian Li and Milagros Ramos and Patricia M{\'a}rmol and Masahisa Horiuchi and Kyoko Shimotsu and Shiro Nakagawa and Akiko Okubo and Munefumi Sameshima and Yasushi Isashiki and Araceli del Arco and Keiko Kobayashi and Jorgina Satr{\'u}stegui and Takeyori Saheki},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 35},
  pages={31333-9}
}
Aralar is a mitochondrial calcium-regulated aspartate-glutamate carrier mainly distributed in brain and skeletal muscle, involved in the transport of aspartate from mitochondria to cytosol, and in the transfer of cytosolic reducing equivalents into mitochondria as a member of the malate-aspartate NADH shuttle. In the present study, we describe the characteristics of aralar-deficient (Aralar-/-) mice, generated by a gene-trap method, showing no aralar mRNA and protein, and no detectable malate… CONTINUE READING

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