Reduced N-acetylaspartate in the temporal cortex of rats reared in isolation.

@article{Harte2004ReducedNI,
  title={Reduced N-acetylaspartate in the temporal cortex of rats reared in isolation.},
  author={Michael K. Harte and Susan B. Powell and Lindsay M Reynolds and Neal R. Swerdlow and Mark A. Geyer and Gavin Paul Reynolds},
  journal={Biological psychiatry},
  year={2004},
  volume={56 4},
  pages={296-9}
}
BACKGROUND Isolation rearing of rats is a nonpharmacologic, nonlesion manipulation that leads to deficits in prepulse inhibition (PPI) and other behavioral and neurochemical alterations reminiscent of schizophrenia. N-acetylaspartate (NAA) is present in high concentrations in the central nervous system and is found primarily in neurons. N-acetylaspartate is considered to be a marker of both neuronal loss and cellular dysfunction. Magnetic resonance spectroscopy studies have shown reductions of… CONTINUE READING