Reduced Mobility of the Alternate Splicing Factor (Asf) through the Nucleoplasm and Steady State Speckle Compartments

@article{Kruhlak2000ReducedMO,
  title={Reduced Mobility of the Alternate Splicing Factor (Asf) through the Nucleoplasm and Steady State Speckle Compartments},
  author={Michael J. Kruhlak and Melody A. Lever and Wolfgang Fischle and Eric Verdin and D. P. Bazett-Jones and Michael J. Hendzel},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={150},
  pages={41 - 52}
}
Compartmentalization of the nucleus is now recognized as an important level of regulation influencing specific nuclear processes. The mechanism of factor organization and the movement of factors in nuclear space have not been fully determined. Splicing factors, for example, have been shown to move in a directed manner as large intact structures from sites of concentration to sites of active transcription, but splicing factors are also thought to exist in a freely diffusible state. In this study… CONTINUE READING
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