Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells

@article{Stefano2018ReducedMI,
  title={Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells},
  author={Bruno Di Stefano and Mai Ueda and Shan Sabri and Justin Brumbaugh and Aaron J. Huebner and Anna Sahakyan and M Kendell Clement and Katie J. Clowers and Alison Russell Erickson and Keiko Shioda and Steven P Gygi and Hongcang Gu and Toshi Shioda and Alexander Meissner and Yasuhiro Takashima and Kathrin Plath and Konrad Hochedlinger},
  journal={Nature Methods},
  year={2018},
  volume={15},
  pages={732-740}
}
Human embryonic stem cells (hESCs) can be captured in a primed state in which they resemble the postimplantation epiblast, or in a naive state where they resemble the preimplantation epiblast. Naive-cell-specific culture conditions allow the study of preimplantation development ex vivo but reportedly lead to chromosomal abnormalities, which compromises their utility in research and potential therapeutic applications. Although MEK inhibition is essential for the naive state, here we show that… CONTINUE READING
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