Reduced Lysosomal Acid Lipase Activity in Adult Patients With Non-alcoholic Fatty Liver Disease

@inproceedings{Baratta2015ReducedLA,
  title={Reduced Lysosomal Acid Lipase Activity in Adult Patients With Non-alcoholic Fatty Liver Disease},
  author={Francesco Baratta and Daniele Pastori and Maria Del Ben and Licia Polimeni and Giancarlo Labbadia and Serena Di Santo and Fiorella Piemonte and Giulia Tozzi and Francesco Violi and Francesco Angelico},
  booktitle={EBioMedicine},
  year={2015}
}
Non-alcoholic fatty liver disease (NAFLD) is characterized by intra-hepatic fat accumulation and mechanisms involved in its pathogenesis are not fully explained. Lysosomal Acid Lipase (LAL) is a key enzyme in lipid metabolism. We investigated its activity in patients with fatty liver. LAL activity (nmol/spot/h) was measured in 100 adult healthy subjects (HS) and in 240 NAFLD patients. A sub-analysis on 35 patients with biopsy-proven non-alcoholic steatohepatitis (NASH) was performed. Median LAL… CONTINUE READING