Reduced Light Response of Neuronal Firing Activity in the Suprachiasmatic Nucleus and Optic Nerve of Cryptochrome-Deficient Mice

@inproceedings{Nakamura2011ReducedLR,
  title={Reduced Light Response of Neuronal Firing Activity in the Suprachiasmatic Nucleus and Optic Nerve of Cryptochrome-Deficient Mice},
  author={Takahiro Nakamura and Shizufumi Ebihara and Kazuyuki Shinohara},
  booktitle={PloS one},
  year={2011}
}
To examine roles of the Cryptochromes (Cry1 and Cry2) in mammalian circadian photoreception, we recorded single-unit neuronal firing activity in the suprachiasmatic nucleus (SCN), a primary circadian oscillator, and optic nerve fibers in vivo after retinal illumination in anesthetized Cry1 and Cry2 double-knockout (Cry-deficient) mice. In wild-type mice, most SCN neurons increased their firing frequency in response to retinal illumination at night, whereas only 17% of SCN neurons responded… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 44 references

Vitamin B2-based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals.

Proceedings of the National Academy of Sciences of the United States of America • 1998
View 15 Excerpts
Highly Influenced

Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice.

Proceedings of the National Academy of Sciences of the United States of America • 2000
View 6 Excerpts
Highly Influenced

Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2.

Proceedings of the National Academy of Sciences of the United States of America • 1999
View 5 Excerpts
Highly Influenced

Circadian organization of the mammalian retina.

Proceedings of the National Academy of Sciences of the United States of America • 2006
View 2 Excerpts

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