Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington’s Disease


Huntington's disease is the result of a long polyglutamine tract in the gene encoding huntingtin protein, which in turn causes a large number of cellular changes and ultimately results in neurodegeneration of striatal neurons. Although many theories have been proposed, the precise mechanism by which the polyglutamine expansion causes cellular changes is not… (More)
DOI: 10.1371/journal.pone.0145333


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