Reduced Isotype Switching in Splenic B Cells from Mice Deficient in Mismatch Repair Enzymes

@article{Schrader1999ReducedIS,
  title={Reduced Isotype Switching in Splenic B Cells from Mice Deficient in Mismatch Repair Enzymes},
  author={Carol E. Schrader and Winfried Edelmann and Raju Kucherlapati and Janet Stavnezer},
  journal={The Journal of Experimental Medicine},
  year={1999},
  volume={190},
  pages={323 - 330}
}
Mice deficient in various mismatch repair (MMR) enzymes were examined to determine whether this repair pathway is involved in antibody class switch recombination. Splenic B cells from mice deficient in Msh2, Mlh1, Pms2, or Mlh1 and Pms2 were stimulated in culture with lipopolysaccharide (LPS) to induce immunoglobulin (Ig)G2b and IgG3, LPS and interleukin (IL)-4 to induce IgG1, or LPS, anti-delta-dextran, IL-4, IL-5, and transforming growth factor (TGF)-beta1 to induce IgA. After 4 d in culture… CONTINUE READING

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