Reduced Interhemispheric Functional Connectivity in the Motor Cortex during Rest in Limb-Onset Amyotrophic Lateral Sclerosis

@inproceedings{JelsoneSwain2010ReducedIF,
  title={Reduced Interhemispheric Functional Connectivity in the Motor Cortex during Rest in Limb-Onset Amyotrophic Lateral Sclerosis},
  author={Laura Jelsone-Swain and Brett W. Fling and Rachael D. Seidler and Rebecca Hovatter and Kirsten L. Gruis and Robert C. Welsh},
  booktitle={Front. Syst. Neurosci.},
  year={2010}
}
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder of motor neurons that leads to paralysis and eventually death. There is evidence that atrophy occurs in the primary motor cortex (M1), but it is unclear how the disease affects the intrinsic connectivity of this structure. Thus, the goal of this study was to examine interhemispheric coupling of low frequency blood-oxygen-level dependent (BOLD) signal fluctuations in M1 using functional connectivity magnetic… CONTINUE READING