Reduced IRE1α mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor

@inproceedings{Son2014ReducedIM,
  title={Reduced IRE1α mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor},
  author={Sung Min Son and J Byun and S E Roh and S. J. Kim and Inhee Mook-jung},
  booktitle={Cell Death and Disease},
  year={2014}
}
The endoplasmic reticulum (ER) is not only a home for folding and posttranslational modifications of secretory proteins but also a reservoir for intracellular Ca2+. Perturbation of ER homeostasis contributes to the pathogenesis of various neurodegenerative diseases, such as Alzheimer’s and Parkinson diseases. One key regulator that underlies cell survival and Ca2+ homeostasis during ER stress responses is inositol-requiring enzyme 1α (IRE1α). Despite extensive studies on this ER membrane… CONTINUE READING
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