Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas.

@article{Bender2013ReducedHA,
  title={Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas.},
  author={Sebastian Bender and Yujie Tang and Anders M. Lindroth and Volker Hovestadt and David T. W. Jones and Marcel Kool and Marc Zapatka and Paul A. Northcott and Dominik Sturm and Wei Wang and Bernhard Radlwimmer and Jonas W H\ojfeldt and Nathal{\`e}ne Truffaux and David Castel and Simone J A Schubert and Marina Ryzhova and Huriye Şeker-Cin and Jan Gronych and Pascal Johann and Sebastian Stark and Jochen Meyer and Till Milde and Martin Schuhmann and Martin Ebinger and Camelia Maria Monoranu and Anitha Ponnuswami and Spenser Y. Chen and C Michael Jones and Olaf Witt and Vincent Peter Collins and Andreas von Deimling and Nada Jabado and S Puget and Jacques Grill and Kristian Helin and Andrey Korshunov and Peter Lichter and Michelle Monje and Christoph Plass and Y Jae Cho and Stefan M. Pfister},
  journal={Cancer cell},
  year={2013},
  volume={24 5},
  pages={660-72}
}
Two recurrent mutations, K27M and G34R/V, within histone variant H3.3 were recently identified in ∼50% of pHGGs. Both mutations define clinically and biologically distinct subgroups of pHGGs. Here, we provide further insight about the dominant-negative effect of K27M mutant H3.3, leading to a global reduction of the repressive histone mark H3K27me3. We demonstrate that this is caused by aberrant recruitment of the PRC2 complex to K27M mutant H3.3 and enzymatic inhibition of the H3K27me3… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 6 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 135 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Similar Papers

Loading similar papers…