Reduced GABAergic inhibition explains cortical hyperexcitability in the wobbler mouse model of ALS.

@article{NietoGonzalez2011ReducedGI,
  title={Reduced GABAergic inhibition explains cortical hyperexcitability in the wobbler mouse model of ALS.},
  author={Jose Luis Nieto-Gonzalez and Jakob Maximilian Moser and Martin Lauritzen and Thomas Schmitt-John and Kimmo Jensen},
  journal={Cerebral cortex},
  year={2011},
  volume={21 3},
  pages={625-35}
}
Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disease of the central nervous system. Symptomatic and presymptomatic ALS patients demonstrate cortical hyperexcitability, which raises the possibility that alterations in inhibitory gamma-aminobutyric acid (GABA)ergic system could underlie this dysfunction. Here, we studied the GABAergic system in cortex using patch-clamp recordings in the wobbler mouse, a model of ALS. In layer 5 pyramidal neurons of motor cortex, the frequency… CONTINUE READING

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