Reduced Food Intake and Body Weight in Mice Deficient for the G Protein-Coupled Receptor GPR82

  title={Reduced Food Intake and Body Weight in Mice Deficient for the G Protein-Coupled Receptor GPR82},
  author={Kathrin M. Engel and Kristin Schr{\"o}ck and Daniel Teupser and Lesca Miriam Holdt and Anke Tönjes and Matthias Kern and Kerstin Dietrich and Peter Kovacs and Ute Kr{\"u}gel and Holger A. Scheidt and J{\"u}rgen Schiller and Daniel Huster and Gudrun A. Brockmann and Martin Augustin and Joachim Thiery and Matthias Bl{\"u}her and Michael Stumvoll and Torsten Sch{\"o}neberg and Angela Schulz},
  journal={PLoS ONE},
G protein-coupled receptors (GPCR) are involved in the regulation of numerous physiological functions. Therefore, GPCR variants may have conferred important selective advantages during periods of human evolution. Indeed, several genomic loci with signatures of recent selection in humans contain GPCR genes among them the X-chromosomally located gene for GPR82. This gene encodes a so-called orphan GPCR with unknown function. To address the functional relevance of GPR82 gene-deficient mice were… 

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