Reduced Expression of nm23 Is Associated with Metastasis of Human Gastric Carcinomas

@inproceedings{Nakayama1993ReducedEO,
  title={Reduced Expression of nm23 Is Associated with Metastasis of Human Gastric Carcinomas},
  author={Hirofumi Nakayama and Wataru Yasui and Hiroshi Yokozaki and Eiichi Tahara},
  booktitle={Japanese journal of cancer research : Gann},
  year={1993}
}
Reduced expression of nm23 gene is implicated in high metastatic potential in a variety of malignancies. To elucidate the role of nm23 in human gastric carcinomas, we examined loss of heterozygosity (LOH) of nm23 gene by Southern blotting, nm23 mRNA expression by Northern blotting and nm23 protein expression by Western blotting as well as immunohistochemistry in both primary and metastatic tumors. LOH of nm23 gene was found in 2 (8%) out of the 23 informative gastric carcinomas. Twenty-two (84… CONTINUE READING

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