Reduced Expression of DNA Damage Repair Genes High Mobility Group Box1 and Poly(ADP-ribose) Polymerase1 in Inactive Carriers of Hepatitis B Virus Infection-A Possible Stage of Viral Integration.

@article{Mukherjee2013ReducedEO,
  title={Reduced Expression of DNA Damage Repair Genes High Mobility Group Box1 and Poly(ADP-ribose) Polymerase1 in Inactive Carriers of Hepatitis B Virus Infection-A Possible Stage of Viral Integration.},
  author={Rathindra Mohan Mukherjee and Gelli V Shravanti and Aparna Jakkampudi and Ramya Prasanthi Kota and Asha L Jangala and P. Balkumar Reddy and Padaki Nagaraja Rao and Rajesh Gupta and Duvvuru Nageshwar Reddy},
  journal={Journal of clinical and experimental hepatology},
  year={2013},
  volume={3 2},
  pages={89-95}
}
BACKGROUND High mobility group box1 (HMGB1) and poly(ADP-ribose) polymerase1 (PARP1) proteins repair cellular DNA damage. Reduced expression of the corresponding genes can lead to an impaired DNA damage repair mechanism. Intracellular replication of hepatitis B virus (HBV) in such conditions can favor the integration of viral DNA into host genome leading to the development of hepatocellular carcinoma (HCC). OBJECTIVE This study was performed to assess the expression of HMGB1 and PARP1 mRNAs… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 37 references

Use of HBsAg serum levels help to distinguish active from inactive hepatitis B virus genotype

  • MR Brunetto, F Oliveri, P Colombatto
  • D carriers. Gastroenterology
  • 2010

Use of HBsAg serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers

  • MR Brunetto, F Oliveri, P Colombatto
  • Gastroenterology
  • 2010

Similar Papers

Loading similar papers…