Reduced ENaC activity and blood pressure in mice with genetic knockout of the insulin receptor in the renal collecting duct.

@article{Li2013ReducedEA,
  title={Reduced ENaC activity and blood pressure in mice with genetic knockout of the insulin receptor in the renal collecting duct.},
  author={Lijun Wu Li and Radha Mayuri Garikepati and Susanna Tsukerman and Donald E Kohan and Jonathan B. Wade and Swasti Tiwari and Carolyn M A Ecelbarger},
  journal={American journal of physiology. Renal physiology},
  year={2013},
  volume={304 3},
  pages={
          F279-88
        }
}
To elucidate the role of the insulin receptor (IR) in collecting duct (CD), we bred mice with IR selectively deleted from CD principal cells using an aquaporin-2 promoter to drive Cre-recombinase expression. Young, adult male knockout (KO) mice had altered plasma and electrolyte homeostasis under high- (HS) and low-sodium (LS) diets, relative to wild-type (WT) littermates. One week of LS feeding led to a significant reduction in urine potassium (K(+)) and sodium (Na(+)) excretion in KO, and a… CONTINUE READING

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