Reduced E-cadherin expression is associated with invasiveness and unfavorable prognosis in breast cancer.

@article{Siitonen1996ReducedEE,
  title={Reduced E-cadherin expression is associated with invasiveness and unfavorable prognosis in breast cancer.},
  author={Sanna M Siitonen and Juha Kononen and Heikki J. Helin and Immo Rantala and Kaija A Holli and Jorma J. Isola},
  journal={American journal of clinical pathology},
  year={1996},
  volume={105 4},
  pages={394-402}
}
E-cadherin (E-cad) is a calcium-dependent, epithelial cell adhesion molecule whose reduced or lost expression has been associated with tumor dedifferentiation and increased metastatic potential in human carcinomas. The authors studied immunohistochemically E-cad expression in frozen sections of 362 breast carcinomas using a monoclonal antibody (HECD-1). The immunohistochemical detection of reduced E-cad expression was confirmed by mRNA in situ hybridization with two different oligonucleotide… CONTINUE READING