Reduced DNA repair capacity for removing tobacco carcinogen-induced DNA adducts contributes to risk of head and neck cancer but not tumor characteristics.

@article{Wang2010ReducedDR,
  title={Reduced DNA repair capacity for removing tobacco carcinogen-induced DNA adducts contributes to risk of head and neck cancer but not tumor characteristics.},
  author={Lei E. Wang and Zhibin Hu and Erich M Sturgis and Margaret R. Spitz and Sara S. Strom and Christopher I. Amos and Zhaozheng Guo and Yawei Qiao and Ann Gillenwater and Jeffrey N. Myers and Gary L Clayman and Randal S. Weber and A El-naggar and Li Mao and Scott Michael Lippman and Waun Ki Hong and Qingyi Wei},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2010},
  volume={16 2},
  pages={764-74}
}
PURPOSE Although cigarette smoking and alcohol use are known risk factors for squamous cell carcinoma of head and neck (SCCHN), only a few exposed individuals develop this disease, suggesting an individual susceptibility. In this study, we investigated the associations between genetically determined DNA repair capacity (DRC) for removing tobacco-induced DNA adducts and risk of SCCHN and tumor characteristics. EXPERIMENTAL DESIGN We measured DRC in cultured T lymphocytes using the host-cell… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia

  • JB van der Net, AC Janssens, JC Defesche, JJ Kastelein, EJ Sijbrands, EW. Steyerberg
  • Am J Cardiol 2009;103:375–80. Clin Cancer Res;
  • 2010
1 Excerpt

Similar Papers

Loading similar papers…