Reduced DEAF1 function during type 1 diabetes inhibits translation in lymph node stromal cells by suppressing Eif4g3.

@article{Yip2013ReducedDF,
  title={Reduced DEAF1 function during type 1 diabetes inhibits translation in lymph node stromal cells by suppressing Eif4g3.},
  author={Linda Yip and R{\'e}mi J Creusot and Cara Teresia Pager and Peter Sarnow and C. Garrison Fathman},
  journal={Journal of molecular cell biology},
  year={2013},
  volume={5 2},
  pages={99-110}
}
The transcriptional regulator deformed epidermal autoregulatory factor 1 (DEAF1) has been suggested to play a role in maintaining peripheral tolerance by controlling the transcription of peripheral tissue antigen genes in lymph node stromal cells (LNSCs). Here, we demonstrate that DEAF1 also regulates the translation of genes in LNSCs by controlling the transcription of the poorly characterized eukaryotic translation initiation factor 4 gamma 3 (Eif4g3) that encodes eIF4GII. Eif4g3 gene… CONTINUE READING
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