Reduced Cognition in Syngap1 Mutants Is Caused by Isolated Damage within Developing Forebrain Excitatory Neurons

@article{Ozkan2014ReducedCI,
  title={Reduced Cognition in Syngap1 Mutants Is Caused by Isolated Damage within Developing Forebrain Excitatory Neurons},
  author={Emin D. Ozkan and Thomas K. Creson and Enik{\"o} A. Kram{\'a}r and Camilo Rojas and Ron R. Seese and Alex H. Babyan and Yulin Shi and Rocco D Lucero and Xiangmin Xu and Jeffrey L Noebels and Courtney A Miller and Gary Lynch and Gavin R Rumbaugh},
  journal={Neuron},
  year={2014},
  volume={82},
  pages={1317-1333}
}
Syngap1 haploinsufficiency is a common cause of sporadic intellectual disability. Syngap1 mutations disrupt developing pyramidal neurons, although it remains unclear if this process contributes to cognitive abnormalities. Here, we found that haploinsufficiency restricted to forebrain glutamatergic neurons was sufficient to disrupt cognition and removing mutations from this population prevented cognitive abnormalities. In contrast, manipulating Syngap1 function in GABAergic neurons had no effect… CONTINUE READING
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Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2002
View 4 Excerpts
Highly Influenced

The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2003
View 6 Excerpts
Highly Influenced

SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2002
View 6 Excerpts
Highly Influenced

Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1999
View 4 Excerpts
Highly Influenced

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