Reduced Cellular Susceptibility to In Vitro HIV Infection Is Associated with CD4+ T Cell Quiescence

@inproceedings{Card2012ReducedCS,
  title={Reduced Cellular Susceptibility to In Vitro HIV Infection Is Associated with CD4+ T Cell Quiescence},
  author={Catherine M. Card and William J Rutherford and Suzie Ramdahin and Xiao-jian Yao and Makobu Kimani and Charles Wachihi and Joshua Kimani and Francis Allan Plummer and Terry Blake Ball and Keith R Fowke},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND HIV preferentially establishes productive infection in activated CD4+ T cells. Since proportions of activated CD4+ T cells vary between individuals, this study aimed to determine if individuals with a greater proportion of activated CD4+ T cells would be more susceptible to in vitro HIV infection. METHODOLOGY/PRINCIPAL FINDINGS Unstimulated peripheral blood mononuclear cells (PBMC) from various donors were inoculated with HIV(ML1956)in vitro. HIV replication was evaluated by HIV… CONTINUE READING
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