Reduced CTLA-4 protein and messenger RNA expression in umbilical cord blood T lymphocytes.

@article{Miller2002ReducedCP,
  title={Reduced CTLA-4 protein and messenger RNA expression in umbilical cord blood T lymphocytes.},
  author={Robin E Miller and John D. Fayen and Shaden F Mohammad and Kevin Stein and Suzanne Kadereit and Kathleen Daum Woods and R. Michael Sramkoski and James W. Jacobberger and Dennis J. Templeton and Susan B. Shurin and Mary J. Laughlin},
  journal={Experimental hematology},
  year={2002},
  volume={30 7},
  pages={738-44}
}
OBJECTIVE A favorable incidence and severity of graft-vs-host disease is observed in patients transplanted with banked, unrelated, HLA-mismatched umbilical cord blood (UCB) grafts, while the incidence of malignant relapse remains low. CTLA-4 mediates negative T-cell signaling and may contribute to the development of allogeneic tolerance. In this study, we compared protein and mRNA expression of CTLA-4 in stimulated UCB and adult peripheral blood T cells. MATERIALS AND METHODS T cells were… CONTINUE READING
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