Reduced CTLA-4 protein and messenger RNA expression in umbilical cord blood T lymphocytes.

  title={Reduced CTLA-4 protein and messenger RNA expression in umbilical cord blood T lymphocytes.},
  author={Robin E Miller and John D. Fayen and Shaden F Mohammad and Kevin Stein and Suzanne Kadereit and Kathleen Daum Woods and R. Michael Sramkoski and James W. Jacobberger and Dennis J. Templeton and Susan B. Shurin and Mary J. Laughlin},
  journal={Experimental hematology},
  volume={30 7},
OBJECTIVE A favorable incidence and severity of graft-vs-host disease is observed in patients transplanted with banked, unrelated, HLA-mismatched umbilical cord blood (UCB) grafts, while the incidence of malignant relapse remains low. CTLA-4 mediates negative T-cell signaling and may contribute to the development of allogeneic tolerance. In this study, we compared protein and mRNA expression of CTLA-4 in stimulated UCB and adult peripheral blood T cells. MATERIALS AND METHODS T cells were… CONTINUE READING
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CD28-specific Ab prevents GVHD in mice

  • XZ Yu, SJ Bidwell, PJ Martin, C Anasetti
  • J Immunol
  • 2000
Highly Influential
11 Excerpts

Reduced NFAT1 protein expression in human UCB T lymphocytes

  • S Kadereit, S Mohammad, R Miller
  • Blood
  • 1999
Highly Influential
3 Excerpts

Involvement of CD40 ligand744 CD40 and CTLA4-B7 pathways in murine acute GVHD induced by allogeneic T cells lacking CD28

  • K Saito, J Sakurai, J Ohata
  • J Immunol
  • 1998
Highly Influential
11 Excerpts

Cyclosporin A effects after primary and secondary activation of human umbilical cord blood T lymphocytes

  • S Kadereit, MM Kozik, GR Junge
  • Exp Hematol
  • 2001
2 Excerpts

Immunologic selftolerance maintained by CD25 CD4 regulatory T cells constitutively expressing CTLA-4

  • T Takahashi, T Tagami, S Yamazaki
  • J Exp Med
  • 2000

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