Reduced C-terminal Src kinase (Csk) activities in hepatocellular carcinoma.

  title={Reduced C-terminal Src kinase (Csk) activities in hepatocellular carcinoma.},
  author={Takayuki Masaki and Mituyoshi Okada and Masaaki Tokuda and Yasushi Shiratori and Osamu Hatase and Mutsunori Shirai and Mikio Nishioka and Masao Omata},
  volume={29 2},
The proto-oncogene product pp60(c-src) is the cellular homologue of the Rous sarcoma transforming gene, and it is a non-receptor-linked and membrane-associated tyrosine kinase. There is a close correlation between elevated pp60(c-src) activity and cell transformation. We have recently reported that pp60(c-src) was activated in hepatocellular carcinoma (HCC) of human and Long-Evans cinnamon (LEC) rats. However, the mechanisms involved in this process remain unknown. C-terminal Src kinase (Csk… CONTINUE READING
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