Reduced C(beta) statistical potentials can outperform all-atom potentials in decoy identification.

@article{Fitzgerald2007ReducedCS,
  title={Reduced C(beta) statistical potentials can outperform all-atom potentials in decoy identification.},
  author={James E. Fitzgerald and Abhishek K Jha and Andr{\'e}s Colubri and Tobin R. Sosnick and Karl F. Freed},
  journal={Protein science : a publication of the Protein Society},
  year={2007},
  volume={16 10},
  pages={2123-39}
}
We developed a series of statistical potentials to recognize the native protein from decoys, particularly when using only a reduced representation in which each side chain is treated as a single C(beta) atom. Beginning with a highly successful all-atom statistical potential, the Discrete Optimized Protein Energy function (DOPE), we considered the implications of including additional information in the all-atom statistical potential and subsequently reducing to the C(beta) representation. One of… CONTINUE READING

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