Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

  title={Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9},
  author={K. Kuida and T. Haydar and C. Kuan and Y. Gu and C. Taya and H. Karasuyama and M. Su and P. Rakic and R. Flavell},
  • K. Kuida, T. Haydar, +6 authors R. Flavell
  • Published 1998
  • Biology, Medicine
  • Cell
  • Caspases are essential components of the mammalian cell death machinery. Here we test the hypothesis that Caspase 9 (Casp9) is a critical upstream activator of caspases through gene targeting in mice. The majority of Casp9 knockout mice die perinatally with a markedly enlarged and malformed cerebrum caused by reduced apoptosis during brain development. Casp9 deletion prevents activation of Casp3 in embryonic brains in vivo, and Casp9-deficient thymocytes show resistance to a subset of apoptotic… CONTINUE READING
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