Reduced Anesthetization during the Intracarotid Amobarbital (Wada) Test in Patients Taking Carbonic Anhydrase–Inhibiting Medications

@article{Bookheimer2005ReducedAD,
  title={Reduced Anesthetization during the Intracarotid Amobarbital (Wada) Test in Patients Taking Carbonic Anhydrase–Inhibiting Medications},
  author={Susan Y. Bookheimer and Lara M. Schrader and Rebecca Rausch and Raman Sankar and Jerome Engel},
  journal={Epilepsia},
  year={2005},
  volume={46}
}
Summary:  Purpose: Failure to show adequate anesthetization during the intracarotid amobarbital procedure (IAP or “Wada test”) is a rare complication. After an unusually high rate of recent anesthetization failures, we sought to determine the frequency of reduced anesthetization and any common factors underlying these failures. 
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Carbonic anhydrase-inhibiting medications and the intracarotid amobarbital procedure in children

REDUCED ANESTHESIA EFFECT OF SODIUM AMYTAL DURING THE INTRACAROTID AMOBARBITAL PROCEDURE IN PEDIATRIC PATIENTS

TLDR
2005 Minnesota Epilepsy Group, P.A., 225 Smith Avenue N., Suite 201 St. Paul, MN 55102 Phone: (651) 241-5290 Fax: (2001) 242-5248.

Drug load and memory during intracarotid amobarbital procedure in epilepsy

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It is suggested that total drug load can be a confounding variable in the IAP memory performance that could explain, at least in part, the reverse asymmetries reported in different studies.

Wada test using secobarbital sodium (Ional) to determine language dominance

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Secobarbital sodium is proposed as a safe and reliable alternative to sodium amobarbitals used in the Wada test to determine language dominance and its efficacy is reported.

Carbonic anhydrase enzymes: Likely targets for inhalational anesthetics.

Anticonvulsant Effects of Carbonic Anhydrase Inhibitors: The Enigmatic Link Between Carbonic Anhydrases and Electrical Activity of the Brain.

  • H. Ozsoy
  • Biology
    Neurochemical research
  • 2021
TLDR
The present study will review the involvement of CAs in the formation of epileptogenesis, and likely mechanisms by which CA inhibitors suppress the electrical activity of the brain.

Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections – anesthetic implications and literature review

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The first case of a patient with PANDAS is described and its anesthesia implications are described, which might be more challenging for anesthesiologists.

Evaluation of the Density Spectral Array in the Wada test: report of six cases.

The Wada Test: Current Perspectives and Applications

TLDR
The Wada test is not only employed to predict postoperative risks of language and memory deficits but is also a marker of temporal lobe dysfunction and as such should be sensitive to seizure-onset laterality in patients with temporal lobe epilepsy.

Drug safety evaluation of zonisamide for the treatment of epilepsy

Introduction: Zonisamide is a broad spectrum antiepileptic drug with multiple mechanisms of action which has been recently approved in the US and Europe as an adjunctive therapy for refractory…

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