Reduced Anesthetization during the Intracarotid Amobarbital (Wada) Test in Patients Taking Carbonic Anhydrase–Inhibiting Medications

@article{Bookheimer2005ReducedAD,
  title={Reduced Anesthetization during the Intracarotid Amobarbital (Wada) Test in Patients Taking Carbonic Anhydrase–Inhibiting Medications},
  author={Susan Y. Bookheimer and Lara M. Schrader and Rebecca Rausch and Raman Sankar and Jerome Engel},
  journal={Epilepsia},
  year={2005},
  volume={46}
}
Summary:  Purpose: Failure to show adequate anesthetization during the intracarotid amobarbital procedure (IAP or “Wada test”) is a rare complication. After an unusually high rate of recent anesthetization failures, we sought to determine the frequency of reduced anesthetization and any common factors underlying these failures. 
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Carbonic anhydrase-inhibiting medications and the intracarotid amobarbital procedure in children
TLDR
The aim of the present study was to investigate the possibility that anesthetization failures are the result of interactions of carbonic anhydrase-inhibiting (CAI) medications with sodium amobarbital, and whether CAI medications interfered with the outcome of these procedures. Expand
REDUCED ANESTHESIA EFFECT OF SODIUM AMYTAL DURING THE INTRACAROTID AMOBARBITAL PROCEDURE IN PEDIATRIC PATIENTS
published: Epilepsia 46(8);82[1.196]2005 Minnesota Epilepsy Group, P.A. ® 225 Smith Avenue N., Suite 201 St. Paul, MN 55102 Phone: (651) 241-5290 Fax: (651) 241-5248
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Secobarbital sodium is proposed as a safe and reliable alternative to sodium amobarbitals used in the Wada test to determine language dominance and its efficacy is reported. Expand
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This article presents a hypothesis that the anesthetic actions of inhalational anesthetics could be due to their inhibitory effects on the carbonic anhydrases, and investigates whether this hypothesis might lead to the development of new safer anesthetic drugs. Expand
Anticonvulsant Effects of Carbonic Anhydrase Inhibitors: The Enigmatic Link Between Carbonic Anhydrases and Electrical Activity of the Brain.
  • H. Ozsoy
  • Medicine
  • Neurochemical research
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The present study will review the involvement of CAs in the formation of epileptogenesis, and likely mechanisms by which CA inhibitors suppress the electrical activity of the brain. Expand
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The first case of a patient with PANDAS is described and its anesthesia implications are described, which might be more challenging for anesthesiologists. Expand
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