Reduced Anesthetization during the Intracarotid Amobarbital (Wada) Test in Patients Taking Carbonic Anhydrase–Inhibiting Medications

@article{Bookheimer2005ReducedAD,
  title={Reduced Anesthetization during the Intracarotid Amobarbital (Wada) Test in Patients Taking Carbonic Anhydrase–Inhibiting Medications},
  author={Susan Y. Bookheimer and Lara M. Schrader and Rebecca Rausch and Raman Sankar and Jerome Engel},
  journal={Epilepsia},
  year={2005},
  volume={46}
}
Summary:  Purpose: Failure to show adequate anesthetization during the intracarotid amobarbital procedure (IAP or “Wada test”) is a rare complication. After an unusually high rate of recent anesthetization failures, we sought to determine the frequency of reduced anesthetization and any common factors underlying these failures. 
Carbonic anhydrase-inhibiting medications and the intracarotid amobarbital procedure in children
TLDR
The aim of the present study was to investigate the possibility that anesthetization failures are the result of interactions of carbonic anhydrase-inhibiting (CAI) medications with sodium amobarbital, and whether CAI medications interfered with the outcome of these procedures. Expand
REDUCED ANESTHESIA EFFECT OF SODIUM AMYTAL DURING THE INTRACAROTID AMOBARBITAL PROCEDURE IN PEDIATRIC PATIENTS
published: Epilepsia 46(8);82[1.196]2005 Minnesota Epilepsy Group, P.A. ® 225 Smith Avenue N., Suite 201 St. Paul, MN 55102 Phone: (651) 241-5290 Fax: (651) 241-5248
Drug load and memory during intracarotid amobarbital procedure in epilepsy
TLDR
It is suggested that total drug load can be a confounding variable in the IAP memory performance that could explain, at least in part, the reverse asymmetries reported in different studies. Expand
Wada test using secobarbital sodium (Ional) to determine language dominance
TLDR
Secobarbital sodium is proposed as a safe and reliable alternative to sodium amobarbitals used in the Wada test to determine language dominance and its efficacy is reported. Expand
Carbonic anhydrase enzymes: Likely targets for inhalational anesthetics.
  • H. Ozsoy
  • Medicine, Biology
  • Medical hypotheses
  • 2019
TLDR
This article presents a hypothesis that the anesthetic actions of inhalational anesthetics could be due to their inhibitory effects on the carbonic anhydrases, and investigates whether this hypothesis might lead to the development of new safer anesthetic drugs. Expand
Anticonvulsant Effects of Carbonic Anhydrase Inhibitors: The Enigmatic Link Between Carbonic Anhydrases and Electrical Activity of the Brain.
  • H. Ozsoy
  • Medicine
  • Neurochemical research
  • 2021
TLDR
The present study will review the involvement of CAs in the formation of epileptogenesis, and likely mechanisms by which CA inhibitors suppress the electrical activity of the brain. Expand
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections – anesthetic implications and literature review
TLDR
The first case of a patient with PANDAS is described and its anesthesia implications are described, which might be more challenging for anesthesiologists. Expand
General Considerations for Neurointerventional Procedures
This chapter is a vade mecum (i.e., an essential guide) for neurointerventionalists, covering fundamental aspects of neurointerventional procedures, including pre-procedural preparation, vascularExpand
The Wada Test: Current Perspectives and Applications
TLDR
The Wada test is not only employed to predict postoperative risks of language and memory deficits but is also a marker of temporal lobe dysfunction and as such should be sensitive to seizure-onset laterality in patients with temporal lobe epilepsy. Expand
Drug safety evaluation of zonisamide for the treatment of epilepsy
Introduction: Zonisamide is a broad spectrum antiepileptic drug with multiple mechanisms of action which has been recently approved in the US and Europe as an adjunctive therapy for refractoryExpand
...
1
2
3
...

References

SHOWING 1-10 OF 37 REFERENCES
Topiramate and Metabolic Acidosis in Pediatric Epilepsy
Summary:  Purpose: Topiramate (TPM) has been widely used as an adjunctive therapy for treating epilepsy. TPM is reported to have multiple mechanisms of action, including inhibition of carbonicExpand
Effects of topiramate on memory performance on the intracarotid amobarbital (Wada) test
TLDR
It is concluded that a possible adverse effect of TPM on memory performance should be considered when evaluating the Wada test memory scores of patients on TPM therapy. Expand
Intracarotid amobarbital test of language and memory before temporal lobectomy for seizure control
TLDR
The intracarotid amobarbital sodium test evaluates the presence of memory and language by pharmacologically inactivating temporarily most of the cerebral hemisphere of the proposed lobectomy, thus minimizing the risk that surgery will impair these functions. Expand
Topiramate induced metabolic acidosis
TLDR
The product design engineers are working on the design of a new port system suitable for both fluid and transfusion sets, and this port system shall be incorporated into the Ecobag once fully tested and validated. Expand
INTRACAROTID INJECTION OF SODIUM AMYTAL FOR THE LATERALIZATION OF CEREBRAL SPEECH DOMINANCE EXPERIMENTAL AND CLINICAL OBSERVATIONS
TLDR
Further studies regarding the technique of intracarotid injection of Sodium Amytal seemed indicated, particularly with regard to the margin of safety in relation to dose and to the effect of accidental injection into the vertebral artery. Expand
Abnormal Wada and Neuropsychological Testing Results Due to Topiramate Therapy
TLDR
Physicians must therefore be cautious in evaluating such test scores while a patient is on topiramate, as his preoperative neuropsychological scores and sodium amytal (Wada) scores were low and may have excluded him from surgery. Expand
Diuretics as Antiepileptic Drugs: Should We Go with the Flow?
TLDR
Potential anticonvulsant mechanisms are discussed in light of the effects of these diuretics on electrolyte balance and synaptic signaling. Expand
Resumption of behavior following intracarotid sodium amobarbital injection
TLDR
A negative effect of an epileptic lesion on the contralateral hemisphere is suggested for intracartid sodium amobarbital injection in patients with unilateral focal temporal lobe epilepsy. Expand
Inhibitory effect of zonisamide on human carbonic anhydrase in vitro.
TLDR
The relative potencies of zonisamide to acetazolamide in inhibiting carbonic anhydrases in human erythrocytes and purified human carbonicAnhydrase I and II in vitro are found to be about 1/150, 1/8 and 1/188, respectively. Expand
Language Disturbances as Side Effects of Topiramate and Zonisamide Therapy
TLDR
Reversible side effects of two sulfa-containing antiepileptic drugs (AEDs), topiramate (TPM) and zonisamide (ZNS), are reported, suggesting that verbal processing is especially sensitive to these sulfA-containing AEDs. Expand
...
1
2
3
4
...