Reduced ABCB1 Expression and Activity in the Presence of Acrylic Copolymers.


PURPOSE P-glycoprotein (P-gp; ABCB1), an integral membrane protein in the apical surface of human intestinal epithelial cells, plays a crucial role in the intestinal transport and efflux leading to changes in the bioavailability of oral pharmaceutical compounds. This study was set to examine the potential effects of three Eudragits RL100, S100 and L100 on… (More)
DOI: 10.5681/apb.2014.032


3 Figures and Tables