Reduced 1alpha-hydroxylase activity in human prostate cancer cells correlates with decreased susceptibility to 25-hydroxyvitamin D3-induced growth inhibition.

@article{Hsu2001Reduced1A,
  title={Reduced 1alpha-hydroxylase activity in human prostate cancer cells correlates with decreased susceptibility to 25-hydroxyvitamin D3-induced growth inhibition.},
  author={J Y Hsu and D Feldman and John E. McNeal and Donna M. Peehl},
  journal={Cancer research},
  year={2001},
  volume={61 7},
  pages={2852-6}
}
  • J Y Hsu, D Feldman, +1 author Donna M. Peehl
  • Published 2001 in Cancer research
Evidence from epidemiological, molecular, and genetic studies suggests a role for vitamin D in the development and/or progression of prostate cancer. In experimental models and clinical trials, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] was shown to exert antiproliferative, prodifferentiating, and antimetastatic/invasive effects on prostatic epithelial cells. Because the direct clinical application of 1,25(OH)2D3 is limited by the major side effect of hypercalcemia, we investigated the potential… CONTINUE READING