Reduced [3H]-tetrodotoxin binding in the nap ts paralytic mutant of Drosophila

  title={Reduced [3H]-tetrodotoxin binding in the nap ts paralytic mutant of Drosophila},
  author={Lawrence M Kauvar},
  journal={Molecular and General Genetics MGG},
The temperature-sensitive paralytic mutant of Drosophila, nap ts, has been shown to have defects in axonal physiology which suggest that it codes for a component of the voltage-sensitive sodium channel. Ligand binding studies using tritiated tetrodotoxin, a sodium channel antagonist, show a decrease in the apparent number of sodium channels in nap ts, providing additional support for this hypothesis. 

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