Redrawing Papez' circuit: a theory about how acute stress becomes chronic and causes disease.

@article{Eggers2007RedrawingPC,
  title={Redrawing Papez' circuit: a theory about how acute stress becomes chronic and causes disease.},
  author={Arnold E. Eggers},
  journal={Medical hypotheses},
  year={2007},
  volume={69 4},
  pages={852-7}
}
The diseases of chronic stress include migraine, essential hypertension, depression, and the metabolic syndrome. A theory is presented to explain how acute stress becomes chronic and causes these inter-related conditions. The theory is based on a new "circuit of emotion", which is derived from Papez' famous theory of emotion. The hypothesis is as follows: There is a basic circuit of emotion which runs from the hippocampus (defined as the dentate gyrus plus the CA regions), where emotion arises… CONTINUE READING

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