Redox-stimuli-responsive drug delivery systems with supramolecular ferrocenyl-containing polymers for controlled release

  title={Redox-stimuli-responsive drug delivery systems with supramolecular ferrocenyl-containing polymers for controlled release},
  author={Haibin Gu and Shengdong Mu and Guirong Qiu and Xiong Liu and Li Zhang and Yanfei Yuan and Didier Astruc},
  journal={Coordination Chemistry Reviews},

Photo and redox dual-stimuli-responsive β-cyclodextrin-ferrocene supramolecules for drug delivery

Amphiphilic photo and redox dual-stimuli-cleavable β-cyclodextrin-ferrocene supramolecules synthesized through noncovalent interactions of ferrocene and β-CD born by 5-hydroxy-2-nitrobenzyl alcohol exhibited almost no toxicity at concentrations up to 1000 μg mL−1.

Formation of H2O2/temperature dual-responsive supramolecular micelles for drug delivery and kinetics

H2O2 and temperature dual-responsive supramolecular micelles prepared from β-cyclodextrin-poly(N-isopropylacrylamide) (β-CD-PNIPAM) star polymer and ferrocene-modified polyethylene glycol (Fc-mPEG) showed higher anti-cancer activity than free drugs and exhibited reversible temperature and redox on–off switch feature.

Oxidant-responsive ferrocene-based cyclodextrin complex coacervate core micelles

A novel ferrocene–dipicolinic acid derivative is presented as redox-responsive subcomponent to be incorporated in cyclodextrin-based coacervate core micelles, C4Ms, with tuneable core structure and responsiveness towards H2O2 treatment.

Recent Advances in Host–Guest Self‐Assembled Cyclodextrin Carriers: Implications for Responsive Drug Delivery and Biomedical Engineering

Cyclodextrin is a relatively low cost, biocompatible, biodegradable, and highly explored material with low toxicity for drug formulation, drug delivery, and wide varieties of other biomedical applications such as those in medical devices fabrication, biosensor, tissue engineering, and bio‐imaging.

Cyclodextrin‐Based Multistimuli‐Responsive Supramolecular Assemblies and Their Biological Functions

In this review, recent progress in CD‐based supramolecular nano assemblies that are sensitive to chemical, biological, and physical stimuli is updated and reviewed, and intriguing examples of the biological functions of these nanoassemblies are presented.

Amphiphilic TEMPO-Functionalized Block Copolymers: Synthesis, Self-Assembly and Redox-Responsive Disassembly Behavior, and Potential Application in Triggered Drug Delivery

A novel range of amphiphilic redox-responsive 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-functionalized diblock copolymers poly(ethylene glycol)-b-poly(2,2,6,6-tetramethylpiperidine-1-oxyl-4-yl

Self-assembly of two ferrocence- and α-cyclodextrin-derived unconventional amphiphiles with redox responsiveness




Self-assembly and disassembly of a redox-responsive ferrocene-containing amphiphilic block copolymer for controlled release

Stimuli-responsive block copolymer micelles have recently emerged as promising drug delivery systems with controllable drug release. Herein, we report well-defined redox-responsive

Voltage-responsive micelles based on the assembly of two biocompatible homopolymers

Voltage stimulus is considered as a clean and simple method in the field of stimuli-responsive polymer systems, and a reversible assembly–disassembly transition of this micellar system was realized, and Voltage-controlled drug release based on this system was conducted successfully.

Reactive Oxygen Species and Glutathione Dual Redox-Responsive Supramolecular Assemblies with Controllable Release Capability.

In vivo results revealed the mPEG-β-CD/Fc-CPT nanoparticles had higher in vivo efficacy without side effects, and it is anticipated this supramolecular complex may serve as a new kind of promising alternative for drug delivery systems.

Preparation and redox-controlled reversible response of ferrocene-modified poly(allylamine hydrochloride) microcapsules.

Because of the excellent redox properties of Fc, the PAH-Fc microcapsules showed redox sensitivity to oxidation and reduction, resulting in reversible swelling and shrinking, leading to the controlled loading and release of desired substances such as dextran.

Enzyme and voltage stimuli-responsive controlled release system based on β-cyclodextrin-capped mesoporous silica nanoparticles.

Mesoporous silica nanoparticles have been functionalized with the ferrocenyl moiety (Fc) which interacts with β-cyclodextrin (β-CD) to form an inclusion complex on the opening of the pores to make the release system a controlled one.

Triple-stimuli-responsive ferrocene-containing homopolymers by RAFT polymerization

Well-defined ferrocene-containing homopolymers were synthesized by RAFT homopolymerization of an acrylate monomer bearing a ferrocene (Fc) unit and an N,N-diethylamino ethyl (DEAE) group, i.e.

Redox-Responsive Vesicles Prepared from Supramolecular 2-Hydroxypropyl-β-Cyclodextrin and Ferrocene Derivative for Drug Delivery

  • Li Xue
  • Chemistry, Materials Science
  • 2015
A novel hydrophobic ferrocene polymer( P-Fc) was synthesized successfully. Taken the advantage of 2-hydroxypropyl-β-cyclodextrin( HP-β-CD) with hydrophilic outside and hydrophobic inside,P-Fc was

Dual-Stimuli-Responsive Nanoassemblies as Tunable Releasing Carriers.

Two end-decorated homopolymers, methoxy polyethylene glycol-ferrocene (mPEG-Fc) and poly(N-isopropylacrylamide)-β-cyclodextrin (PNIPAM-β-CD), were further orthogonally self-assembled into stable