Redox status of high-mobility group box 1 performs a dual role in angiogenesis of colorectal carcinoma

@inproceedings{Zhu2015RedoxSO,
  title={Redox status of high-mobility group box 1 performs a dual role in angiogenesis of colorectal carcinoma},
  author={Lingyin Zhu and Lin Ren and Yingxuan Chen and Jingyuan Fang and Zhi-Zheng Ge and Xiaobo Li},
  booktitle={Journal of cellular and molecular medicine},
  year={2015}
}
During inflammation, high-mobility group box 1 in reduced all-thiol form (at-HMGB1) takes charge of chemoattractant activity, whereas only disulfide-HMGB1 (ds-HMGB1) has cytokine activity. Also as pro-angiogenic inducer, the role of HMGB1 in different redox states has never been defined in tumour angiogenesis. To verify which redox states of HMGB1 induces angiogenesis in colorectal carcinoma. To measure the expression of VEGF-A and angiogenic properties of the endothelial cells (ECs), at-HMGB1… CONTINUE READING
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