Redox state of cytochrome c regulates cellular ROS and caspase cascade in permeablized cell model.

Abstract

In a permeablized cell system, oxidized cyt c is able to induce caspase cascade whereas reduced cyt c cannot. In in vitro experiments, oxidized cyt c can promote H(2)O(2) generation. It is suggested that the redox state of cyt c might regulate the initiation of apoptosis via regulation of cellular ROS level.

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@article{Li2008RedoxSO, title={Redox state of cytochrome c regulates cellular ROS and caspase cascade in permeablized cell model.}, author={Min Li and Ao-Jin Wang and Jian-xing Xu}, journal={Protein and peptide letters}, year={2008}, volume={15 2}, pages={200-5} }