Redox-silent tocotrienol esters as breast cancer proliferation and migration inhibitors.

  title={Redox-silent tocotrienol esters as breast cancer proliferation and migration inhibitors.},
  author={Fathy A. Behery and Ahmed Y O Elnagar and Mohamed R. Akl and Vikram B. Wali and Bilal S. Abuasal and Amal Kaddoumi and Paul William Sylvester and Khalid A El Sayed},
  journal={Bioorganic & medicinal chemistry},
  volume={18 22},
Tocotrienols are vitamin E members with potent antiproliferative activity against preneoplastic and neoplastic mammary epithelial cells with little or no effect on normal cell growth or functions. However, physicochemical and pharmacokinetic properties greatly limit their use as therapeutic agents. Tocotrienols' chemical instability, poor water solubility, NPC1L1-mediated transport, and rapid metabolism are examples of such obstacles which hinder the therapeutic use of these valuable natural… CONTINUE READING
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